I do the bulk of my sanding using random orbit air sanders.(DA's) I have one I use with under 100 grit, and a newer one I use with 120 and up. These always wear out on the outer radius while the center is barely affected. When I remove them I fold them in half and use them for hand sanding with the benefits pmspirito described.
I ran across an article which changed the way I sand things. It suggested using no finer than 150 grit for finish sanding since this allows for all finishes to adhere properly to the wood. Before I would of sanded to at least 220 with no thought that it could cause the finish to fail prematurely.
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Mike |