How many pieces do you plan on making? One? A bunch? However, I usually make a master (or template as some call 'em), even if I'm only gonna make one - that way, if I change my mind later and want more all the hard work has already been done.
And, yeah, I sometimes flip mine to be symmetrical, but the other guys pretty much have that covered.
I make mine out of 1/2" plywood - that's what I like. Make one perfect piece, glue it to more plywood, then rout using the first as your guide - this gives a master 1" thick, lots of heft to hold on to. I drill pilot holes and tack my master down to the piece to be routed. I can pump out clones one after another that way - with what I do and how I do it, the nail holes are never seen in the finished doohickey, or whatever. I am NOT recommending you do yours this way, just telling you how I do mine, but if you want to give it a shot, more power to you.
"It ain't what you're told, it's what you know." - Granny Weatherwax
Some days, the supply of available curse words is insufficient to meet my demands.
Call me a craftsman, artisan, or artistic, and I will accept that. Call me an artist and you will likely get a quite rude comment in return. I am not a @#$%ing artist.