For such material a vacuum bed would probably be the best solution. The Meteor MDF top can be removed an a torsion box/vacuum box could be hung inside the frame.
For the little experience I have cutting acrylic on a CNC I used t-track clamps around the perimeter, and tabs to keep the parts in place as they were cut.
You could just pre-drill and screw your acrylic sheets down to the MDF bed. Be sure and not put a screw anywhere the bit may run.
I'm going to recommend you intentionally try many strategies. That's the only guarantee you'll figure out what works best for your specific needs.
4D
For the little experience I have cutting acrylic on a CNC I used t-track clamps around the perimeter, and tabs to keep the parts in place as they were cut.
You could just pre-drill and screw your acrylic sheets down to the MDF bed. Be sure and not put a screw anywhere the bit may run.
I'm going to recommend you intentionally try many strategies. That's the only guarantee you'll figure out what works best for your specific needs.
4D
