That's a hard one to answer! I need to know the size and thickness of the wood, the size of the project. I would then more than likely run some letters, and look at the size, and if it will be properly sized to be seen. Smaller letters will use a smaller cut, and so on. That is what I find Myself doing, nd it works the best! Have fun!
I agree with Howard - adjust the bit depth based on the size of the lettering, and plan the thickness of the stock accordingly. This can vary based on the style of lettering, as well - i.e., whether the lettering is raised or inset, and whether it will be accentuated by paint or stain. One-inch lettering might require only 1/8" or so, 3"-4" might work with 1/4" depth, larger lettering might need 1/2" or more. In general, I like to keep the depth of cut to 1/3 the thickness of the stock, or less.
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