Most glass shops carry 2 types of plastic. Acrylic [Plexiglas and Lucite are brand names] or Polycarbonate [Lexan]. Polycarbonate can be cut, routed or drilled just like wood. And is a lot stronger. Special bits are made for drilling Acrylic to prevent chipping but I have made my own as they are just regular bits ground at a much sharper angle. Also over time Acrylic tends to crack from any holes you've drilled. Whichever you choose if your going to rough it out with a bandsaw or jigsaw, use a fairly coarse wood blade. Most people try a thin fine tooth blade but often the cut will melt back together behind the blade.
Rusty
Rusty