If you are talking about Gorilla Wood Glue, it is a PVA glue that seems very similar to Titebond II from Gorilla's website, but I've never used it. Modern PVA glues are so good that I wouldn't hesitate to try it.
I have used Original Gorilla polyurethane glue. Can't seem to keep it off my hands, and it doesn't clean up with water like Titebond. It's sticky and just plain messy. I only use it when I need a truly waterproof (instead of weatherproof) glue. I would never consider it a proper substitute for PVA. I have the same problem of it going hard in the bottle after opening, so I buy the smallest bottle. You can make it last a little longer by squeezing all the air out of the bottle before closing it. I use a small quick grip clamp to squeeze the bottle until the glue comes up into the spout and then put the top on. It still gets hard if stored for a month or more.
“We should be careful to get out of an experience only the wisdom that is in it and stop there lest we be like the cat that sits down on a hot stove lid. She will never sit down on a hot stove lid again and that is well but also she will never sit down on a cold one anymore.” - Mark Twain