Gmercer, As for experience I have run a commercial shop for 30+ years. We've had a Castle pocket screw machine for many years. It occasionally gets used on plywood but I'm not a fan of the stuff. 80% of what we build is made with Industrial grade particle with melamine or HPL (not the crap sold at the big box stores.) 8% MDF, 2% ply. Oldcrumudgeon has been tainted by having used/ bought stuff that used the cheap cheap board. We ship our store fixtures all over the country and to a few off shore locations. They make the trip just fine and hold up for years in rather hostile retail environments. I don't know where the home shop guy can buy industrial board, we get it through distribution yards.
As for why I hate to use ply: The stuff has voids (usually right where a screw goes,) it is prone to not being flat, it is never true to thickness. This last point is extremely important for production use. All of our products are parametrically designed in CAD. Optimized & Coded by CAM software, sent to CNC machines from the office server (Router, beam saw, edgebander, bore and insert & case clamp.) Face dowel holes are done on the Router, edge doweling is done on the bore & insert (slick machine, 8' long working area, reads a bar code, drills, blows the dust out, injects glue, drives a dowel, moves to the next location in 1.5 seconds. At the case clamp glue is injected with a gun that measures an exact amount. Drawer guides, hinge plates etc. are installed. Case is loosely knocked together and slid into the clamp. Push button, ass'l the next case. Time in clamp, about 3-4 minutes. Occasionally there will be a screwup and the wrong size case will be made. It becomes our test victim. Virtually all commercial work is frameless construction. Properly made it is very durable. I suspect few home shops have the equipment to do it.